Needle-less® Serum

(Park of 1)

$50.99 $65.99

Needle-less® Serum

1 fl oz
Experience smoother, firmer, and deeply hydrated skin—no injections required. This multitasking serum combines our proprietary CeraPep™ Technology with targeted peptides, ceramides, and sodium hyaluronate to visibly refine texture, calm visible redness, and support a healthy-looking skin barrier. It’s a simplified solution that helps skin look more radiant, balanced, and youthful.

Visibly softens the look of fine lines and wrinkles
Improves the appearance of firmness and elasticity
Energizes dull-looking skin for a refreshed appearance
Helps reduce visible redness and soothe sensitive-looking skin

$50.99 $65.99

Our products are manufactured both locally and globally. We carefully select our manufacturing partners to ensure our products are high quality and a fair value.

4 Reasons Everyone Loves Needle-less® Serum

1. Cosmo’s “Best Peptide Serum”

This serum works. But don't take our word for it—Cosmopolitan named it the "Best Peptide Serum" in 2023.

3. Visibly Diminishes Fine Lines

Enriched with potent actives clinically proven to visibly improve the look of fine lines and wrinkles around the mouth, eyes, and forehead.

2. Dramatic Anti-aging Results You Can See

This active-packed serum is loaded with anti-aging superstars like Hyaluronic Acid, Niacinamide, and our proprietary Cerapep® Technology: a revolutionary blend of restorative peptides & ceramides.

4. Brighten the Look of Pigmentation

Niacinamide strengthens the skin’s moisture barrier, while improving the look of pigmentation and pore appearance.

Dramatic Anti-aging Results

You Can See After 6 Weeks

94%

saw healthier-looking skin

91%

had firmer-feeling skin

94%

said skin felt smoother

Based on a six-week independent consumer panel

Before and After 60 Days Of Use

When used as directed. Unedited and not retouched. Results may vary.

Full Description

As skin matures, it can begin to look less firm and smooth, with more visible lines and uneven texture. Daily exposure to environmental stressors and overuse of harsh products can also weaken the skin’s protective barrier, making it appear more prone to dryness and visible redness. Needle-less® Serum was created to help address these visible signs of aging and restore a look of balance, comfort, and vitality.

Our proprietary CeraPep™ Technology combines three skin-identical ceramides with a targeted peptide blend to replenish essential lipids and support the look of a stronger, more resilient skin barrier. This dual-action formula helps improve the appearance of firmness, visibly smooth texture, and deliver lasting hydration. To further calm and refine the complexion, we included niacinamide, a form of vitamin B3 known to help reduce visible redness, minimize the look of pores, and promote an even-looking tone.

Deep hydration is essential for maintaining a youthful-looking complexion. Sodium hyaluronate, a form of hyaluronic acid with a smaller molecular weight, attracts and retains moisture to help visibly plump and smooth the look of fine lines. Meanwhile, pea extract and copper peptides help improve the appearance of elasticity and radiance for a more revitalized look.

Whether you’re looking to extend the benefits of your professional treatments or prefer a non-invasive option, Needle-less® Serum seamlessly fits into any skincare routine.

CRUELTY
FREE

DERMATOLOGIST
RECOMMENDED

SULFATE
FREE

PARABEN
FREE

GLUTEN
FREE

FRAGRANCE
FREE

Frequently asked questions

Yes, this serum is suitable for all skin types, including sensitive and oily skin. lt's a perfect serum for those wanting anti-aging results without a heavy feel or irritation.

Yes, this serum pairs perfectly with retinoids in your evening routine. Apply serum first,allow to absorb fully before applying retinoid.

Consistency and patience is key. You will start to notice results in a few weeks but werecommend using 2X a day for 6-8 weeks to see real results.

Apply to slightly damp skin as the first step in your AM & PM routine after cleansing andtoning.

Absolutely! This serum will prolong results of your injectables. lf you do not getiniectables, this makes for a perfect non-inyasive alternative option.

Skin Concerns

Redness

Firmness

Wrinkles

Dryness

Post Procedure

Skin Types

Normal

Dry

Combination

Oily

How to Layer Your DRMTLGY Products

MORNING

NIGHT

OUR STORY

Science-Backed Skincare, Simplified.

DRMTLGY was born of the belief that evidence-based, dermatological skincare should be available to everyone. With a rich, 20-year history in skincare manufacturing and deep roots in the dermatology community, we saw first-hand that skincare companies are overcharging their customers for medical grade ingredients.

This is what Medical Grade means to us:

We partnered with world-class chemists and expert dermatologists to create proprietary formulas with the best of ingredients. We committed to combining the art of formulation with the science of skin because we believe everyone should have access to safe, effective skincare—without unnecessary markups.

After more than a decade of extensive research, clinical testing, and physician feedback, we’re proud to offer a diverse selection of more than 40 clinically effective products for all skin types, tones, concerns, and ages. To date, we’ve transformed over 4 million skincare routines—and we’re just getting started.

Clinically Effective Ingredients, Delivered

We follow the strictest protocols to ensure every product we create is dermatologist-backed, safe for skin, and does what it says it will.

Rooted in Research—Always.

No shade on celebrities, but we prefer our skincare to be rooted in research. Our products are formulated in partnership with expert chemists, tested rigorously in the lab, and approved by our board of certified dermatologists before they ever hit your doorstep.

Meet our Board of Dermatologists

Our board of renowned dermatologists brings together years of expertise in skincare, research, and medical innovation. With a shared commitment to advancing dermatological science, they play a crucial role in developing and refining our formulations. Get to know the experts shaping the future of skincare.

Dr. Ariana Eginli

MD, FAAD

Dr. Ariana Eginli is a practicing board-certified Dermatologist in Southern California, who is skilled in treating patients with complex dermatologic conditions, cosmetics, and hair and scalp disorders. She strives to educate her patients and make them feel comfortable in their own skin.

Dr. Brittany Oliver

MD, FAAD

Dr. Oliver is a board-certified dermatologist practicing in the Kansas City metro area. Recognized as a Castle Connolly Rising Star in 2023 and 2024, she is passionate about delivering individualized care to diverse patients of all ages and backgrounds.

Dr. Marisa Garshick

MD, FAAD

Selected as New York SuperDoctors in 2021, she has a passion for being able to improve patient’s quality of life and loves to help her patients look and feel their best. She previously worked for the Dr. Oz Show and has been featured in many publications including Woman’s Health and Elle.

OUR MISSION

No one should struggle with their skin—or their confidence—and real solutions can change everything.

We believe skincare is more than self-care—it’s a lifeline when your skin feels like your biggest challenge. Whether it’s acne, dark spots, sensitivity, or signs of aging, we know how much problem skin can impact your confidence and how you show up in the world. That’s why we create dermatologist-grade, clinically proven skincare that targets real concerns with compassion, precision, and science. Because the moment you see your skin change is the moment you start to feel like yourself again. And we believe everyone deserves to feel confident in their own skin.

Customer reviews

While this isnt like botox it does work! I have purchased multiple bottles and lines on my face have decreased by adding it into my routine. It will not give major or quick results but when used frequently you can tell a difference! I do recommend it

-Jennifer

I love dermatology. I definitely can tell the difference when I don't have this on. My skin looks and feels plumper when I use this. I use it at night and in the morning before any lotion or products. Highly recommend this serum!

-Kim

Have had prescription and over the counter retinol and DRMTLGY, as recommended by YouTube dermatologist, Dr. Sugai is by far the best! I've seen amazing changes in a short period of time. I thank you as does my face and hands!

-SK